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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine Jo-1 antibodies to (histidyl transfer RNA synthetase). Circulating Jo-1 antibodies are present in some autoimmune connective-tissue diseases, particularly in polymyositis, a chronic, progressive inflammatory disease of the skeletal muscles; polymyositis frequently occurs with inflammatory skin changes (i.e., dermatomyositis). Patients suffering polymyositis may have associated interstitial lung disease.
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