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  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of amikacin, a semisynthetic aminoglycoside bactericidal agent present in the sample. Amikacin is used in the treatment of a wide variety of aerobic gram-negative bacteria and also for some gram-positive bacteria. Reagents for measuring amikacin levels are used monitor the therapeutic drug levels in patients undergoing treatment, either to determine the adequacy of drug treatment or to diagnose a drug overdose or antibiotic-related toxicity. Typical reference levels in blood, in micrograms per milliliter, are peak 20 to 25, predose (trough) 5 to 10, and toxic more than 35.
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