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Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum, plasma) to determine the level of proinsulin, an amino acid polypeptide with low biological activity that is the major storage form of insulin. Increased levels of proinsulin may be sufficient to produce hypoglycemia; high levels of proinsulin are also found in patients with chronic renal failure, cirrhosis, hyperthyroidism, or beta-cell tumors in the pancreas.
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