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Hematology reagents used in screening tests to determine the time required to form a fibrin clot when a sample of plasma is added to a thromboplastin-calcium mixture. Prothrombin time (PT) and the derived international normalized ratio (INR) are measures of possible factor deficiencies of the extrinsic pathway of coagulation; the reagents are used in tests to determine the clotting tendency of blood, vitamin K status, and to regulate warfarin dose.
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