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Molecular assay reagents intended to identify mutations in the rearranged during transfection (RET) gene, located at chromosome 10q11.2, which encodes for a receptor tyrosine kinase that transduces signals for cell growth and differentiation. It is essential for the development of several kinds of nerve cells, kidney development, and sperm production. These genetic mutations have been identified in patients with several diseases, including multiple endocrine neoplasia type 2 (MEN2), both type II A (MEN 2A, Sipple\'s syndrome) and type II B (MEN 2B), and Hirschsprung\'s disease1.
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