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  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of total carbamazepine, an anticonvulsant and antineuralgic drug mostly used in the treatment of tonic-clonic and partial seizures typical of epilepsy and in pain associated to trigeminal neuralgia. Carbamazepine in blood is highly bound (about 76%) to proteins in plasma, but only free carbamazepine and its metabolite carbamazepine-10, 11-epoxide are bioactive. Reagents for measuring levels of total carbamazepine are intended to monitor therapeutic drug levels or to diagnose a drug overdose or drug-related toxicity.
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