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Immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum or urine) to determine luteinizing hormone (LH), one of the hormones that control the functional activity of the gonads (i.e., gonadotropins). In females, LH causes release of the ovum from the ovarian follicle and, following ovulation, the transformation of the ruptured follicle into the corpus luteum (luteinization). In males LH is frequently called stimulating hormone or interstitial cell stimulating hormone because it stimulates testosterone production. High levels of LH in women are found in primary amenorrhea, ovariectomy, polycystic ovarian diseases, pituitary or hypothalamic tumors and after administration of oral contraceptives. High levels in men are caused by primary testicular failure and testicular feminization syndrome. LH is vital for human reproduction.
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