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  • Molecular assay reagents intended for use in detecting methylation of DNA encoding the O-6-methylguanine-DNA methyltransferase (MGMT) gene, located at chromosome 10p26, which encodes the protein methylated-DNA--protein-cysteine methyltransferase. Methylation of MGMT DNA has been associated with response of cancers (in particular glioblastoma) to treatment with alkylating agents (e.g., temozolomide) and radiation therapy.
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