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  • Genetically modified, autologous T lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Lewis-Y (LeY), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-LeY-CAR-transduced autologous T lymphocytes specifically target and induce selective toxicity in LeY-expressing tumor cells. LeY, a difucosylated carbohydrate antigen, is overexpressed by a variety of cancer cell types. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132683\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C132683\' NCI Thesaurus)
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