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  • Materials designed prevent the loss of liquid (e.g., blood, spinal fluid) or gas from an anatomic structure through the formation of a mechanical barrier (i.e., seal). In the case of hemorrhage control, tissue sealants are capable of acting independently of the body\'s clotting mechanism. Tissue sealants are frequently supplied in a dedicated applicator containing two separated components, typically a polymer precursor (i.e., monomer) and a polymerization initiator. Mixing of the components at the time of application leads to the formation of a polymer (e.g., hydrogel) that forms a mechanical barrier to liquid/gas leakage. Tissue sealants may be synthetic or biologic in nature and may be used during various surgical procedures to control fluid loss (e.g., hemorrhage) or air loss.
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