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  • A vaccine composed of a replication-deficient chimpanzee adenovirus, ChAdOx1, encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunomodulating and anti-viral activities. Upon administration, ChAdOx1 nCoV-19 expresses the SARS-CoV-2 SP, which induces a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.
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