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  • Human OGA wild-type allele is located in the vicinity of 10q24.32 and is approximately 34 kb in length. This allele, which encodes protein O-GlcNAcase, is involved in the removal of N-acetylglucosamine (GlcNAc) moieties from O-glycosylated proteins. A translocation t(1;10)(p22;q24) which fuses this gene and the TGFBR3 gene may be involved in some low-grade spindle cell mesenchymal neoplasms.
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