?:abstract
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The Kidney Disease Improving Global Outcomes (KDIGO) (2013) Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease provides details on which patients would benefit from the use of statins Potential risk factors for elevated serum creatinine included decreased kidney function, increased age, and high-dose fenofibrate therapy Due to their effects on renal hemodynamics, use of concurrent angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were considered to play a role in increasing the serum creatinine Finding concurrent use of statins and fenofibrates did not further improve CV benefits, the Food and Drug Administration in 2015 withdrew approval for these combination therapies (U S Department of Health and Human Services, 2016)
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