PropertyValue
?:abstract
  • SARS CoV-2 a pandemic influenza like infectious disease emerged in December 2019 has spread throughout the world within few months Scientists are trying their best to find medicine and vaccine Usnic acid and its derivatives as herbal supplements are widely used as mouth wash, cosmetics, antiviral agents In this study, usnic acid and its derivative-sodium usnate in comparison with favipiravir are docked with main protease and spike protein RBD /bb6M0J of SARS Cov-2 Usnic acid and sodium usnate exhibit better binding affinities for main protease and spike RBD The data has been compared with favipiravir Favipiravir, usnic acid, sodium usnate shows binding affinity of -4 25, -8 05 and -8 55 kcal/mol respectively with main protease While favipiravir, usnic acid and sodium usnate exhibit binding affinities of -4 25, -6 02 and -6 53 kcal/mol with spike RBD respectively One of the interesting features is that the inhibition constant values of usnic acid is 1 27 µM and sodium usnate is 539 86 nM in comparison to favipiravir (764 13 µM) with main protease /b
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Docking Studies of Usnic Acid and Sodium Usnate on SARS CoV-2 Main Protease and Spike Protein RBD
?:type
?:who_covidence_id
  • #339
?:year
  • 2020

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