PropertyValue
?:abstract
  • Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a panel of bacteria, including Gram-negative and resistant strains. Ferrocene QACs were shown to be effective antiseptics, with bisQAC Fe-11,11 displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
is ?:annotates of
?:creator
?:journal
  • ChemMedChem_(Internet)
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
?:type
?:who_covidence_id
  • #33197298
?:year
  • 2020

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