PropertyValue
?:abstract
  • BACKGROUND: SARS-CoV-2 outbreaks remains a medical and economic challenge, due to the lack of a suitable drug or vaccine The glycan in some proteins plays an important role in protein folding, sorting, transport, and oligomerization, so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion Tunicamycin anticancer drug inhibits the N-linked glycan AIM: This study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins RESULTS: The growth of the virus in the presence of tunicamycin conducted in the production of non-infectious and absence of spike protein (spikeless virions) Tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses Tunicamycin has also diminished glycosylation of PTMs such as HE, and 8ab of SARS-CoV Finally, CONCLUSION: This study recommends using this drug to treat the SARS-CoV-2 © 2020 Ali Adel Dawood, Haitham Abdul-Malik Alnori
is ?:annotates of
?:creator
?:journal
  • Open_Access_Macedonian_Journal_of_Medical_Sciences
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Tunicamycin anticancer drug may reliable to treat coronavirus disease-19
?:type
?:who_covidence_id
  • #914584
?:year
  • 2020

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