c1tgnj5g

Property	Value
?:abstract	SIMPLE SUMMARY: Coronaviruses are worldwide distributed RNA-viruses affecting several species, causing a broad spectrum of diseases with a zoonotic potential and the ability to jump from one host species to a different one, including humans. In the perspective of ‘One Health’ and the well-known recent Coronavirus-associated epidemics and pandemic, the aim of this review is to list all the animal species affected by Coronaviruses and to describe the lesions and the target organs. Information is given on the pathogenesis and the gross and histological lesions of pets, ferrets, bovines, sheep, goats, equine, swine, wild animals, non-human primates, marine mammals, laboratory animals, fish, reptiles, amphibian, and, briefly, humans. ABSTRACT: Coronaviruses (CoVs) are worldwide distributed RNA-viruses affecting several species, including humans, and causing a broad spectrum of diseases. Historically, they have not been considered a severe threat to public health until two outbreaks of COVs-related atypical human pneumonia derived from animal hosts appeared in 2002 and in 2012. The concern related to CoVs infection dramatically rose after the COVID-19 global outbreak, for which a spill-over from wild animals is also most likely. In light of this CoV zoonotic risk, and their ability to adapt to new species and dramatically spread, it appears pivotal to understand the pathophysiology and mechanisms of tissue injury of known CoVs within the “One-Health” concept. This review specifically describes all CoVs diseases in animals, schematically representing the tissue damage and summarizing the major lesions in an attempt to compare and put them in relation, also with human infections. Some information on pathogenesis and genetic diversity is also included. Investigating the lesions and distribution of CoVs can be crucial to understand and monitor the evolution of these viruses as well as of other pathogens and to further deepen the pathogenesis and transmission of this disease to help public health preventive measures and therapies.
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?:creator	<https://research.tib.eu/covid-19/entity/Zappulli%2C_Valentina%3B_Ferro%2C_Silvia%3B_Bonsembiante%2C_Federico%3B_Brocca%2C_Ginevra%3B_Calore%2C_Alessandro%3B_Cavicchioli%2C_Laura%3B_Centelleghe%2C_Cinzia%3B_Corazzola%2C_Giorgia%3B_De_Vreese%2C_Steffen%3B_Gelain%2C_Maria_Elena%3B_Mazzariol%2C_Sandro%3B_Moccia%2C_Valentina%3B_Rensi%2C_Nicol%C3%B2%3B_Sammarco%2C_Alessandro%3B_Torrigiani%2C_Filippo%3B_Verin%2C_Ranieri%3B_Castagnaro%2C_Massimo>
?:doi	<https://research.tib.eu/covid-19/entity/10.3390/ani10122377>
?:doi	10.3390/ani10122377
?:journal	Animals_(Basel)
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/a618db167e28fce0d32651be334b37fd5305977b.json
?:pmc_json_files	document_parses/pmc_json/PMC7764021.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7764021>
?:pmid	<https://research.tib.eu/covid-19/entity/33322366.0>
?:pmid	33322366.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/c1tgnj5g_HAS_C0012634_AFFECTS_C3714514>
?:sha_id	<https://research.tib.eu/covid-19/entity/a618db167e28fce0d32651be334b37fd5305977b>
?:source	Medline; PMC
?:title	Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-11

Property

Value

?:abstract

SIMPLE SUMMARY: Coronaviruses are worldwide distributed RNA-viruses affecting several species, causing a broad spectrum of diseases with a zoonotic potential and the ability to jump from one host species to a different one, including humans. In the perspective of ‘One Health’ and the well-known recent Coronavirus-associated epidemics and pandemic, the aim of this review is to list all the animal species affected by Coronaviruses and to describe the lesions and the target organs. Information is given on the pathogenesis and the gross and histological lesions of pets, ferrets, bovines, sheep, goats, equine, swine, wild animals, non-human primates, marine mammals, laboratory animals, fish, reptiles, amphibian, and, briefly, humans. ABSTRACT: Coronaviruses (CoVs) are worldwide distributed RNA-viruses affecting several species, including humans, and causing a broad spectrum of diseases. Historically, they have not been considered a severe threat to public health until two outbreaks of COVs-related atypical human pneumonia derived from animal hosts appeared in 2002 and in 2012. The concern related to CoVs infection dramatically rose after the COVID-19 global outbreak, for which a spill-over from wild animals is also most likely. In light of this CoV zoonotic risk, and their ability to adapt to new species and dramatically spread, it appears pivotal to understand the pathophysiology and mechanisms of tissue injury of known CoVs within the “One-Health” concept. This review specifically describes all CoVs diseases in animals, schematically representing the tissue damage and summarizing the major lesions in an attempt to compare and put them in relation, also with human infections. Some information on pathogenesis and genetic diversity is also included. Investigating the lesions and distribution of CoVs can be crucial to understand and monitor the evolution of these viruses as well as of other pathogens and to further deepen the pathogenesis and transmission of this disease to help public health preventive measures and therapies.

is ?:annotates of