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?:abstract
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BACKGROUND: During the outbreak of coronavirus disease 2019 (COVID-19) many studies have investigated laboratory biomarkers in management and prognostication of COVID-19 patients, however to date, few have investigated arterial blood gas (ABG), acid-base and blood pressure (BP) patterns The aim of the study is to assess the ABG and acid-base patterns, BP findings and their association with the outcomes of COVID-19 patients admitted to an intensive care unit (ICU) METHODS: A single-centre retrospective, observational study in a dedicated COVID-19 ICU in Cape Town, South Africa Admission ABG, serum electrolytes, renal function and BP readings performed on COVID-19 patients admitted between 26 March and 2 June 2020 were analysed and compared between survivors and non-survivors RESULTS: A total of 56 ICU patients had admission ABG performed at the time of ICU admission An alkalaemia (pH > 7 45) was observed in 36 (64 3%) patients A higher arterial pH [median 7 48 (IQR: 7 45-7 51 vs 7 46 (IQR: 7 40-7 48), p=0 049] and partial pressure of oxygen in arterial blood [PaO2;median 7 9kPa (IQR 7 3- 9 6) vs 6 5kPa (IQR: 5 2-7 3), p=<0 001] were significantly associated with survival Survivors also tended to have a higher systolic BP [median: 144mmHg (IQR: 134- 152) vs 139mmHg (IQR: 125-142), p=0 078] and higher arterial HCO3 [median: 28 0mmol/L (IQR: 25 7- 28 8) vs 26 3mmol/L (IQR: 24 3-27 9);p=0 059) CONCLUSIONS: The majority of the study population admitted to ICU had an alkalaemia on ABG A higher pH and lower PaO2 on ABG analysis were significantly associated with survival
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