PropertyValue
?:abstract
  • Identification and development of effective drugs active against SARS-CoV-2 are urgently needed. Here, we report on the anti-SARS-CoV-2 activity of MEDS433, a novel inhibitor of human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidines biosynthesis. MEDS433 inhibits in vitro virus replication in the low nanomolar range, and through a mechanism that stems from its ability to block hDHODH activity. MEDS433 thus represents an attractive candidate to develop novel anti-SARS-CoV-2 agents.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1101/2020.12.06.412759
?:externalLink
?:journal
  • bioRxiv
?:license
  • biorxiv
?:publication_isRelatedTo_Disease
?:source
  • BioRxiv; WHO
?:title
  • The new generation hDHODH inhibitor MEDS433 hinders the in vitro replication of SARS-CoV-2
?:type
?:year
  • 2020-12-07

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