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ABSTRACT We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in the absence of an identifiable eliciting drug A 35-year old male without previous known comorbidities was admitted after he was diagnosed with the COVID-19 infection and had large pulmonary involvement Seven days later, he desaturated but was without any signs of respiratory distress A check of arterial blood gas revealed normal partial pressure of oxygen and follow-up tests confirmed a methemoglobinemia diagnosis Over the next few days, hemolysis was established after decreased levels of hemoglobin and increased levels of indirect bilirubin and lactate dehydrogenase A hemolytic anemia investigation panel came back normal, including G6PD A second G6PD test was ordered at the 5-month follow-up appointment and revealed decreased levels Clinicians should thus be aware of possible false negative tests when testing for G6PD during hemolytic crisis In addition, whether the COVID-19 infection alone would be responsible for this chain of events remains a challenging question
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Methemoglobinemia and Hemolytic Anemia after COVID-19 Infection Without Identifiable Eliciting Drug: A Case-Report
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