PropertyValue
?:abstract
  • Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 functions as a transcriptional repressor that inhibits expression of the inflammatory cytokines in macrophages. Critically ill patients with COVID-19 infection often present signs of high oxidative stress and systemic inflammation – the leading causes of mortality. This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.
?:creator
?:doi
  • 10.1134/s0006297920070111
?:doi
?:journal
  • Biochemistry_(Mosc)
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/f2dde841d404142fc2d5dcac6f8efa43b05ecd77.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7356136.xml.json
?:pmcid
?:pmid
?:pmid
  • 33040727.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients
?:type
?:year
  • 2020-07-13

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