d962fcwj

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?:abstract	RATIONALE No direct comparisons of clinical features, laboratory values, and outcomes between critically ill patients with COVID-19 and influenza in the United States have been reported. OBJECTIVE To evaluate the risk of mortality comparing critically ill patients with COVID-19 to seasonal influenza. METHODS We retrospectively identified patients admitted to the intensive care units (ICUs) at two academic medical centers with laboratory confirmed SARS-CoV-2 or influenza A or B infections between January 1, 2019 and April 15, 2020. Clinical data were obtained by medical record review. All patients except one had follow-up to hospital discharge or death. We used relative risk regression adjusting for age, sex, number of comorbidities, and maximum sequential organ failure scores (SOFA) on ICU day 1 to determine the risk of hospital mortality and organ dysfunction in patients with COVID-19 compared to influenza. RESULTS We identified 65 critically ill patients with COVID-19 and 74 with influenza. The mean (± standard deviation) age in each group was 60.4 +/- 15.7 and 56.8 +/- 17.6 years, respectively. Patients with COVID-19 were more likely to be male, have higher body mass index and higher rates of chronic kidney disease and diabetes. Thirty-seven percent of COVID-19 patients identified as Hispanic, compared to 10% of influenza patients. A similar proportion of patients had fever (~40%) and lymphopenia (~80%) on hospital presentation. Rates of acute kidney injury and shock requiring vasopressors were similar between the groups. While need for invasive mechanical ventilation was also similar in both groups, patients with COVID-19 had slower improvements in oxygenation, longer durations of mechanical ventilation, and lower rates of extubation compared to patients with influenza. Hospital mortality was 40% in COVID-19 patients and 19% in influenza patients (adjusted relative risk 2.13, 95% confidence interval 1.24 to 3.63; p = 0.006). CONCLUSIONS Need for invasive mechanical ventilation was common in ICU patients with COVID-19 or influenza. Compared to those with influenza, ICU patients with COVID-19 had worse respiratory outcomes, including longer duration of mechanical ventilation. Additionally, patients with COVID-19 were at greater risk for in-hospital mortality, independent of age, sex, co-morbidities, and ICU severity of illness.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C0015967> <https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C0036974> <https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C0042397> <https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C0349410> <https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C3714514> <https://research.tib.eu/covid-19/entity/d962fcwj_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Cobb%2C_Natalie_L%3B_Sathe%2C_Neha_A%3B_Duan%2C_Kevin_I%3B_Seitz%2C_Kevin_P%3B_Thau%2C_Matthew_R%3B_Sung%2C_Clifford_C%3B_Morrell%2C_Eric_D%3B_Mikacenic%2C_Carmen%3B_Kim%2C_H_Nina%3B_Liles%2C_W_Conrad%3B_Luks%2C_Andrew_M%3B_Town%2C_James%3B_Pipavath%2C_Sudhakar%3B_Wurfel%2C_Mark_M%3B_Hough%2C_Catherine_L%3B_West%2C_T_Eoin%3B_Bhatraju%2C_Pavan_K>
?:doi	<https://research.tib.eu/covid-19/entity/10.1513/annalsats.202007-805oc>
?:doi	10.1513/annalsats.202007-805oc
?:journal	Annals_of_the_American_Thoracic_Society
?:license	unk
?:pmid	<https://research.tib.eu/covid-19/entity/33183067.0>
?:pmid	33183067.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	Medline
?:title	Comparison of Clinical Features and Outcomes in Critically Ill Patients Hospitalized with COVID-19 versus Influenza.
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-13

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Value

?:abstract

RATIONALE No direct comparisons of clinical features, laboratory values, and outcomes between critically ill patients with COVID-19 and influenza in the United States have been reported. OBJECTIVE To evaluate the risk of mortality comparing critically ill patients with COVID-19 to seasonal influenza. METHODS We retrospectively identified patients admitted to the intensive care units (ICUs) at two academic medical centers with laboratory confirmed SARS-CoV-2 or influenza A or B infections between January 1, 2019 and April 15, 2020. Clinical data were obtained by medical record review. All patients except one had follow-up to hospital discharge or death. We used relative risk regression adjusting for age, sex, number of comorbidities, and maximum sequential organ failure scores (SOFA) on ICU day 1 to determine the risk of hospital mortality and organ dysfunction in patients with COVID-19 compared to influenza. RESULTS We identified 65 critically ill patients with COVID-19 and 74 with influenza. The mean (± standard deviation) age in each group was 60.4 +/- 15.7 and 56.8 +/- 17.6 years, respectively. Patients with COVID-19 were more likely to be male, have higher body mass index and higher rates of chronic kidney disease and diabetes. Thirty-seven percent of COVID-19 patients identified as Hispanic, compared to 10% of influenza patients. A similar proportion of patients had fever (~40%) and lymphopenia (~80%) on hospital presentation. Rates of acute kidney injury and shock requiring vasopressors were similar between the groups. While need for invasive mechanical ventilation was also similar in both groups, patients with COVID-19 had slower improvements in oxygenation, longer durations of mechanical ventilation, and lower rates of extubation compared to patients with influenza. Hospital mortality was 40% in COVID-19 patients and 19% in influenza patients (adjusted relative risk 2.13, 95% confidence interval 1.24 to 3.63; p = 0.006). CONCLUSIONS Need for invasive mechanical ventilation was common in ICU patients with COVID-19 or influenza. Compared to those with influenza, ICU patients with COVID-19 had worse respiratory outcomes, including longer duration of mechanical ventilation. Additionally, patients with COVID-19 were at greater risk for in-hospital mortality, independent of age, sex, co-morbidities, and ICU severity of illness.

is ?:annotates of