PropertyValue
?:abstract
  • Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
?:creator
?:journal
  • Aging_(Albany_NY)
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
?:type
?:who_covidence_id
  • #1000742
?:year
  • 2020

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