g5adhns6

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?:abstract	Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19) We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy Overall, 66 COVID-19 patients (mean age 74 +/- 16 6 years;29 females) were enrolled Three patients (4 5%;1 female) had been splenectomised and were excluded from further analyses Fifty-five patients (87 3%) had IgM memory B cell depletion, and 18 (28 6%) died during hospitalisation (cumulative incidence rate 9 26/100 person-week;5 8-14 7 95% CI) All patients who died had IgM memory B cell depletion A superimposed infection was found in 6 patients (9 5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3 08/100 person-week;1 3-6 8 95% CI) At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count <1500/mu l were not correlated with IgM memory B cell depletion A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8-14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3-6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/g5adhns6_hasAnnotation_C0013227>
?:creator	<https://research.tib.eu/covid-19/entity/Lenti%2C_M._V.%3B_Aronico%2C_N.%3B_Pellegrino%2C_I.%3B_Boveri%2C_E.%3B_Giuffrida%2C_P.%3B_de_Andreis%2C_F._B.%3B_Morbini%2C_P.%3B_Vanelli%2C_L.%3B_Pasini%2C_A.%3B_Ubezio%2C_C.%3B_Melazzini%2C_F.%3B_Rascaroli%2C_A.%3B_Antoci%2C_V.%3B_Merli%2C_S.%3B_Di_Terlizzi%2C_F.%3B_Sabatini%2C_U.%3B_Cambie%2C_G.%3B_Tenore%2C_A.%3B_Picone%2C_C.%3B_Vanoli%2C_A.%3B_Arcaini%2C_L.%3B_Baldanti%2C_F.%3B_Paulli%2C_M.%3B_Corazza%2C_G._R.%3B_Di_Sabatino%2C_A.> <https://research.tib.eu/covid-19/entity/Lenti%2C_Marco_Vincenzo%3B_Aronico%2C_Nicola%3B_Pellegrino%2C_Ivan%3B_Boveri%2C_Emanuela%3B_Giuffrida%2C_Paolo%3B_Borrelli_de_Andreis%2C_Federica%3B_Morbini%2C_Patrizia%3B_Vanelli%2C_Laura%3B_Pasini%2C_Alessandra%3B_Ubezio%2C_Cristina%3B_Melazzini%2C_Federica%3B_Rascaroli%2C_Alessandro%3B_Antoci%2C_Valentina%3B_Merli%2C_Stefania%3B_Di_Terlizzi%2C_Francesco%3B_Sabatini%2C_Umberto%3B_Cambi%C3%A8%2C_Ginevra%3B_Tenore%2C_Annamaria%3B_Picone%2C_Cristina%3B_Vanoli%2C_Alessandro%3B_Arcaini%2C_Luca%3B_Baldanti%2C_Fausto%3B_Paulli%2C_Marco%3B_Corazza%2C_Gino_Roberto%3B_Di_Sabatino%2C_Antonio>
?:journal	Sci_Rep Scientific_Reports
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	WHO
?:title	Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1059918 #951598
?:year	2020

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?:abstract

Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19) We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy Overall, 66 COVID-19 patients (mean age 74 +/- 16 6 years;29 females) were enrolled Three patients (4 5%;1 female) had been splenectomised and were excluded from further analyses Fifty-five patients (87 3%) had IgM memory B cell depletion, and 18 (28 6%) died during hospitalisation (cumulative incidence rate 9 26/100 person-week;5 8-14 7 95% CI) All patients who died had IgM memory B cell depletion A superimposed infection was found in 6 patients (9 5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3 08/100 person-week;1 3-6 8 95% CI) At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count <1500/mu l were not correlated with IgM memory B cell depletion A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections
Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8-14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3-6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.

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