PropertyValue
?:abstract
  • The 2019 novel coronavirus (2019-nCoV) is currently causing a widespread outbreak centered on Hubeprovince, China and is a major public health concern Taxonomically 2019-nCoV is closely related to SARS-CoV and SARS-related bat coronaviruses, and it appears to share a common receptor with SARS-CoV (ACE-2) Here, we perform structural modeling of the 2019-nCoV spike glycoprotein Our data provide support for the similar receptor utilization between 2019-nCoV and SARS-CoV, despite a relatively low amino acid similarity in the receptor binding module Compared to SARS-CoV, we identify an extended structural loocontaining basic amino acids at the interface of the receptor binding (S1) and fusion (S2) domains, which we predict to be proteolytically-sensitive We suggest this looconfers fusion activation and entry properties more in line with MERS-CoV and other coronaviruses, and that the presence of this structural looin 2019-nCoV may affect virus stability and transmission
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation looas a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses
?:type
?:who_covidence_id
  • #480
?:year
  • 2020

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/DB00295_interactsWith_DB00593>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/DB00295_interactsWith_DB00593>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all