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?:abstract
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Although emerging data demonstrated mortality of young COVID-19 patients, no data have reported the risk factors of mortality for these young patients, and whether obesity is a risk for young COVID-19 patients remains unknown We conducted a retrospective study including 13 young patients who died of COVID-19 and 40 matched survivors Logistic regression was employed to characterize the risk factors of mortality in young obese COVID-19 patients Most of the young deceased COVID-19 patients were mild cases at the time of admission, but the disease progressed rapidly featured by a higher severity of patchy shadows (100 00% vs 48 70%;P = 006), pleural thickening (61 50% vs 12 80%;P = 012), and mild pericardial effusion (76 90% vs 0 00%;P < 001) Most importantly, the deceased patients manifested higher body mass index (odds ratio [OR] = 1 354;95% confidence interval [CI] = 1 075-1 704;P = 010), inflammation-related index C-reactive protein (OR = 1 014;95% CI = 1 003-1 025;P = 014), cardiac injury biomarker hs-cTnI (OR = 1 420;95% CI = 1 112-1 814;P = 005), and increased coagulation activity biomarker D-dimer (OR = 418 7;P = 047), as compared with that of survivors Our data support that obesity could be a risk factor associated with high mortality in young COVID-19 patients, whereas aggravated inflammatory response, enhanced cardiac injury, and increased coagulation activity are likely to be the mechanisms contributing to the high mortality
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