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The purpose is to analyze the potential association of each antibiotic consumption rate and use ratio with COVID-19 morbidity and mortality, and to investigate the efficacy and safe use of antibiotics against COVID-19. Design Retrospective statistical analysis of antibiotic use compared with COVID-19 morbidity and mortality. Methods Each antibiotic defined daily dose per 1000 inhabitants per day as each antibiotic consumption rate was available in the official reports and each antibiotic use ratio data was calculated from them. Coronavirus disease data were obtained from the WHO Coronavirus Disease Dashboard. The relationships between the sum of defined daily dose, each antibiotic defined daily dose, each antibiotic use ratio, and COVID-19 morbidity and mortality were examined. The statistical correlation was calculated by univariate linear regression analysis and expressed by Pearson\'s correlation coefficient. Results Cephalosporins were a negative correlation with mortality and morbidity. Penicillin had a weak positive correlation with them. Macrolides, quinolone, and sulfonate showed a slightly negative correlation tendency with mortality. Conclusions Cephalosporins may affect less morbidity and mortality. Penicillin suggests to accelerate them. The combination of cephalosporins with macrolides or quinolones may be a helpful treatment.
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10.1101/2020.10.15.20213603
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document_parses/pdf_json/f3723b2a53531db30ed630df33f9e28f5add78ae.json
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Risks and Benefits of Antibiotics vs. COVID-19 Morbidity and Mortality
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