PropertyValue
?:abstract
  • In late December 2019, several cases of pneumonia of unknown etiology (COVID-19) were reported in Wuhan, Hubei province, China. Based on clinical findings, blood tests and chest radiographs, this disease was diagnosed as a virus-associated pneumonia. Sequence analysis revealed a novel coronavirus, called SARS-CoV-2 (formerly called 2019-nCoV), as the causative agent of pneumonia of unknown etiology. So far, the SARS-CoV-2 infection continues to spread, and this virus poses a serious public health threat. In this study, it was aimed to reveal potential miRNA targets for the regulation of SARS-CoV-2 host cell receptor ACE2. For the identification of potential miRNA targets for the ACE2 gene, TarBase v.8 (DIANA Tools), TargetScan, miRTarBase and miRDB miRNA-target prediction algorithms were used. FANTOM5 CAGE was used for the cellular ontology analysis. Expression levels of these miRNAs were determined using OncomiR Pan-Cancer miRNome Atlas. The results suggest that members of miR-200 family of miRNAs, especially miR-200c-3p, are strong candidate targets for the regulation of ACE2 in respiratory system cells. Consequently, the present study for the first time emphasizes potential use of miRNA-based therapeutics in the battle against SARS-CoV-2 infection and its deadly disease, COVID-19.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.mgene.2020.100831
?:doi
?:journal
  • Meta_Gene
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/0e91b0af062295179da81a362a4d8a405f294fe9.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7672338.xml.json
?:pmcid
?:pmid
?:pmid
  • 33224734.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2
?:type
?:year
  • 2020-11-18

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