PropertyValue
?:abstract
  • We reviewed factors that might influence COVID-19 outcomes (eg, neurological symptoms), including the link to Alzheimer\'s disease. Since the virus triggers COVID-19 infection through binding to ACE2, we focused on the ACE2 gene family, including ACE. Both ACE2 and ACE are involved in the renin-angiotensin system (RAS). In general, ACE causes inflammation and vasoconstriction, while ACE2 leads to anti-inflammation activity and vasodilation. The disturbed balance between these counter-regulatory pathways could influence susceptibility to COVID-19. Notably, dysregulation of the RAS-equilibrium contributes to Alzheimer\'s disease. Differences in the incidence and symptoms of COVID-19 in diverse populations could be attributed to variability in the human genome. For example, ACE and ACE2 variations could modify the outcome of COVID-19 in different populations. It would be important to conduct genome-wide studies to detect variants influencing COVID-19 presentation, with a special focus on variants affecting immune-related pathways and expression of RAS-related genes.
?:creator
?:journal
  • Neurosci_Insights
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • The Intersection between COVID-19, the Gene Family of ACE2 and Alzheimer\'s Disease
?:type
?:who_covidence_id
  • #947928
?:year
  • 2020

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