klnxnxwm

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?:abstract	INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS: We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. RESULTS: A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65). CONCLUSION: Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/klnxnxwm_hasAnnotation_C0009566> <https://research.tib.eu/covid-19/entity/klnxnxwm_hasAnnotation_C0027627> <https://research.tib.eu/covid-19/entity/klnxnxwm_hasAnnotation_C0036572> <https://research.tib.eu/covid-19/entity/klnxnxwm_hasAnnotation_C0242656> <https://research.tib.eu/covid-19/entity/klnxnxwm_hasAnnotation_C1415068>
?:creator	<https://research.tib.eu/covid-19/entity/Hussein%2C_Mohammad_H.%3B_Toraih%2C_Eman_A.%3B_Attia%2C_Abdallah_S.%3B_Burley%2C_Nicholas%3B_Zhang%2C_Allen_D.%3B_Roos%2C_Jackson%3B_Houghton%2C_August%3B_Aniemeka%2C_Nedum%3B_Omar%2C_Mahmoud%3B_Aboueisha%2C_Mohamed%3B_Shama%2C_Mohamed_A.%3B_Duchesne%2C_Juan%3B_Kandil%2C_Emad>
?:doi	10.1016/j.rmed.2020.106205
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.rmed.2020.106205>
?:journal	Respir_Med
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/8d25490ea255942217bd21e0da92c79c4822f539.json
?:pmc_json_files	document_parses/pmc_json/PMC7657611.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7657611>
?:pmid	<https://research.tib.eu/covid-19/entity/33217538.0>
?:pmid	33217538.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/klnxnxwm_HAS_C0004096_AFFECTS_C0242656>
?:sha_id	<https://research.tib.eu/covid-19/entity/8d25490ea255942217bd21e0da92c79c4822f539>
?:source	Elsevier; Medline; PMC
?:title	Asthma in COVID-19 patients: An extra chain fitting around the neck?
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-11

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?:abstract

INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS: We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. RESULTS: A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65). CONCLUSION: Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes.

is ?:annotates of