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?:abstract
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Objective: To analyze the antibody levels and dynamic changes in patients infected with 2019-novel coronavirus(2019-nCoV) Methods: The average age of 72 corona virus disease 2019 (COVID-19) patients was (45 53±16 74)years(median age:47 year), including (44 88±17 09) years(median age:46 year) for 38 males and (46 32±16 52)years (median age:46 year) for 34 females in Loudi City, Hunan Province There is no significant difference in genders between the severe and mild groups (χ²=0 916, P>0 05) There is a significant difference in the age between the severe and mild groups (F=3 315, P0 05) The average concentrations of IgG in 1-7 days, 8-14 days, 15-21 days, 22-28 days, 29 days and above were 169 90 (92 06-190 91) AU/ml, 163 89 (91 19-208 02) AU/ml, 173 31 (95 06-191 28) AU/ml, 122 84 (103 19-188 34) AU/ml, 101 98 (43 75-175 30) AU/ml, respectively, (H=2 232, P>0 05) The IgM becomes negative after the 3rd week of discharge and decreases rapidly with time The IgG concentration higher than IgM during the same period, and keep at high level without any change, and decrease in the fourth week Among them, 5 cases developed \'re-infection\' within 1-3 weeks after discharge, and the rate of \'re-infection\' was 6 94% (5/72 cases) Conclusions: After the COVID-19 patients are discharged from the hospital, the level of antibodies produced varies greatly among individuals, but the overall changes in antibodies have a certain pattern It is recommended to strengthen the antibody monitoring during hospitalization and after discharge from the hospital to reduce the \'re-infection\' rate and potential risk of infection
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