PropertyValue
?:abstract
  • The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), RNA-targeting CRISPR-Cas systems and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.tibs.2020.11.010
?:doi
?:journal
  • Trends_Biochem_Sci
?:license
  • els-covid
?:pdf_json_files
  • document_parses/pdf_json/2a88461dab43e4c74946c7ad244bb99f96f08ae4.json
?:pmcid
?:pmid
?:pmid
  • 33309323.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Nucleic acid-based technologies targeting coronaviruses
?:type
?:year
  • 2020-11-27

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