PropertyValue
?:abstract
  • Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future perspectives to increase our understanding of this multifaceted UBL in health and disease.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3390/biom10111557
?:externalLink
?:journal
  • Biomolecules
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/81eb6b0fd966223ef1271bc25f83feb92f9c507e.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7698331.xml.json
?:pmcid
?:pmid
?:pmid
  • 33203188
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • More than Meets the ISG15: Emerging Roles in the DNA Damage Response and Beyond
?:type
?:year
  • 2020-11-15

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