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St Luke\'s International Hospital had been accepting a large number of patients with mild to severe COVID-19, before COVID-19 became a designated infectious disease on February 1, 2020 The first patient with COVID-19 admitted to our hospital was a man in his 40s from Wuhan, the second case of COVID-19 registered in Japan, and officially, the first case in a person of Chinese origin in Japan The third patient, a Canadian man in his 60s who contracted the infection in the cruise ship, Diamond Princess, had very severe disease However, his clinical symptoms improved and he was discharged from the hospital In this paper, we discuss four cases of COVID-19
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