lr4qh67u

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?:abstract	PURPOSE: Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. METHODS: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. RESULTS: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66–85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46–65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25–2.42, p = 0.001; 66–85 years: aOR 1.93, 95% CI 1.36–2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49–3.81, p < 0.001 vs. individuals aged 26–45 years], male sex (aOR 1.23, 95% CI 1.01–1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09–1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04–1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. CONCLUSION: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01499-0) contains supplementary material, which is available to authorized users.
?:creator	<https://research.tib.eu/covid-19/entity/Jakob%2C_Carolin_E._M.%3B_Borgmann%2C_Stefan%3B_Duygu%2C_Fazilet%3B_Behrends%2C_Uta%3B_Hower%2C_Martin%3B_Merle%2C_Uta%3B_Friedrichs%2C_Anette%3B_Tometten%2C_Lukas%3B_Hanses%2C_Frank%3B_Jung%2C_Norma%3B_Rieg%2C_Siegbert%3B_Wille%2C_Kai%3B_Gr%C3%BCner%2C_Beate%3B_Klinker%2C_Hartwig%3B_Gersbacher-Runge%2C_Nicole%3B_Hellwig%2C_Kerstin%3B_Eberwein%2C_Lukas%3B_Dolff%2C_Sebastian%3B_Rauschning%2C_Dominic%3B_von_Bergwelt-Baildon%2C_Michael%3B_Lanznaster%2C_Julia%3B_Strau%C3%9F%2C_Richard%3B_Trauth%2C_Janina%3B_de_With%2C_Katja%3B_Ruethrich%2C_Maria%3B_Lueck%2C_Catherina%3B_Nattermann%2C_Jacob%3B_Tscharntke%2C_Lene%3B_Pilgram%2C_Lisa%3B_Fuhrmann%2C_Sandra%3B_Classen%2C_Annika%3B_Stecher%2C_Melanie%3B_Schons%2C_Maximilian%3B_Spinner%2C_Christoph%3B_Vehreschild%2C_J%C3%B6rg_Janne>
?:doi	<https://research.tib.eu/covid-19/entity/10.1007/s15010-020-01499-0>
?:doi	10.1007/s15010-020-01499-0
?:journal	Infection
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/89b04039da182f93bcd149916ad087a81651b397.json
?:pmc_json_files	document_parses/pmc_json/PMC7527665.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7527665>
?:pmid	<https://research.tib.eu/covid-19/entity/33001409.0>
?:pmid	33001409.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/89b04039da182f93bcd149916ad087a81651b397>
?:source	Medline; PMC
?:title	First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-01

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?:abstract

PURPOSE: Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. METHODS: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. RESULTS: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66–85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46–65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25–2.42, p = 0.001; 66–85 years: aOR 1.93, 95% CI 1.36–2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49–3.81, p < 0.001 vs. individuals aged 26–45 years], male sex (aOR 1.23, 95% CI 1.01–1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09–1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04–1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. CONCLUSION: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01499-0) contains supplementary material, which is available to authorized users.

?:creator