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SESSION TITLE: Critical Care Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: Diabetes has been shown in recent studies to be highly prevalent in critically ill patients with severe coronavirus disease 2019 (COVID-19) However, data comparing clinical outcomes in diabetic and non-diabetic patients remained limited We aim to compare characteristics and clinical outcomes of diabetic and non-diabetic critically ill patients with severe COVID-19 METHODS: Following institutional review board approval, we identified 115 patients who were admitted to the intensive care unit (ICU) for severe COVID-19 De-identified patient data was retrospectively collected and analyzed using Stata version 15 1 (StatCorp) Data reported here are those which are available through April 28 2020 RESULTS: We identified 115 patients who were admitted to the ICU for severe COVID-19 The population had a mean age of 63 44 years, 67% were male, the mean BMI was 33 30 The mean duration of symptoms prior to hospitalization was 6 35 days Comorbidities were common, 68 patients had a Charlson comorbidities index equal to or above 3 The most common comorbidities included hypertension (65%), diabetes (41%) and hyperlipidemia (35%) The most common symptoms were dyspnea (81%), cough (75%) and fever (68%) When comparing the 47 diabetic and the 68 non-diabetic patients in our study, there was a similar number of patients requiring invasive (65% diabetic;51% non-diabetic) and non-invasive mechanical ventilation (36% diabetic;48% non-diabetic) There were no significant differences in their clinical management Both populations had similar rates of shock requiring vasopressors (57% diabetic;48% non-diabetic) and renal failure requiring renal replacement therapy (27% diabetic;25% non-diabetic) There were no significant differences in the rate of acute kidney injury (61% diabetics;40% non-diabetics) and acute hepatic injury between both groups (27% diabetics;22% non-diabetics) Diabetic patients had significantly higher rates of troponin elevation (89% diabetics;70% non-diabetic) After propensity score matching, diabetics were more likely to experience in hospital mortality (OR 2 94 CI 1 32;6 52, p-value 0 008) and were less likely to be discharged from the hospital (OR 0 38 CI 0 17;0 83, p-value 0 02) when compared with non-diabetics CONCLUSIONS: Diabetics experience higher rates of mortality and are less likely to be discharged when compared with non-diabetic patients CLINICAL IMPLICATIONS: Further studies to evaluate management strategies in diabetic patients with severe COVID-19 may be useful given the increased risk for mortality in this population DISCLOSURES: No relevant relationships by Yasmin Herrera, source=Web Response No relevant relationships by Kam Sing Ho, source=Web Response No relevant relationships by Raymonde Jean, source=Web Response No relevant relationships by Joseph Poon, source=Web Response
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