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INTRODUCTION COVID-19 infection with no known specific drugs or vaccines has impacted mankind and has become beyond precedence. Currently, re-purposing of existing drugs is the only therapeutic option for managing COVID-19 symptoms and associated co-infections to reduce mortality. Antimicrobials as varied as anti-parasitic, anti-viral and antibiotics are under various stages of evaluation. AREAS COVERED Recently, doxycycline, a broad spectrum antibiotic which has also reported anti-viral and anti-inflammatory properties was widely investigated in clinical trials, either alone or in combination with other drugs and repurposed for COVID-19 treatment. In the review, the potential therapeutic applications of doxycycline in COVID-19 treatment and its potential adverse implications with respect to antimicrobial resistance bestowed by repurposing the antibiotic has been expounded. EXPERT OPINION \'Fighting disease with already existing antibiotics\' and \'antimicrobial resistance progression\' are like two arms of a balance that has to be carefully equilibrated. Any imbalance by inappropriate or indiscriminate use of repurposed drug would cause a disastrous increase in antimicrobial resistance (AMR). Hence, cautious parallel assessment of potential long-term consequences of AMR is of great importance to mankind as its impacts would prevail even after the current pandemic.
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10.1080/14787210.2021.1865803
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Expert_review_of_anti-infective_therapy
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Potential Effectiveness and Adverse Implications of Repurposing Doxycycline in COVID-19 Treatment.
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