|
?:abstract
|
-
ackground: COVID-19 caused by SARS-CoV-2 in December 2019 has become a pandemicphazard to the community health It is a respiratory difficulty causing fever, dry cough, fatigue,pshortness of breath, muscle aches and some instances lead to pneumonia Coronaviruses haveplarge viral RNA Genomes and are single-stranded positive-sense RNA viruses The nsp10/nsp16pprotein is an important target because it is essential for the virus to replicate, the papain-likepprotease (Nsp3), the main protease (Nsp5), the primary RNA-dependent RNA polymerasep(Nsp12) are also attractive drug targets for this disease The uses of phytochemicals asTherapeutic agents have been increasing in recent years Some antiviral phytochemicals wereptaken based on literature survey for this study pMethods: ADME parameters and drug like nature of phytochemicals were screened usingpSwissADME wetool Three dimensional structures of targets are downloaded from ProteinpData Bank and docked with phytochemicals & control by using software FlexX pResults: Morin shows significant results in ADME screening and Drug likeness predictionpstudies, it shows stable bonding pattern with all four targets in compare to other phytochemicalspand control, shows least score in docking and forms maximum number of hydrogen bonds withThe active residues of the receptors pConclusion: Based on present observation of docking results, ADME parameters and drug likepnature, we suggest that morin may be a potent new drug candidate against Covid-19 pKeywords: COVID-19, coronavirus, drug target, phytochemicals, Drug likeness, ADME,pdocking, morin
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}