PropertyValue
?:abstract
  • Remdesivir was recently approved to treat COVID-19. While this antiviral agent delivers clinical benefits, several safety concerns in many cases have been raised. This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. CES2 is a major drug-metabolizing enzyme. The combination of high potency with irreversible inhibition concludes that cautions must be exercised when remdesivir is used along with drugs hydrolyzed by CES2.
?:creator
?:journal
  • Fundam._clin._pharmacol
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions
?:type
?:who_covidence_id
  • #998909
?:year
  • 2020

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