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?:abstract
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Aim: The present study aims to evaluate the prognostic value of liver-related laboratory parameters in COVID-19 Background: This is not the first nor will it be the last time that a member of the β-coronaviruses wages a full-scale war against human health Notwithstanding atypical pneumonia being the primary symptom, the emergence of severe disease mainly resulting from the injury of non-pulmonary organs leaves no alternative, in some cases, other than a dreadful death Methods: To provide a well-conceptualized viewpoint representing the prognostic values of liver-related laboratory parameters in COVID-19, a meta-analysis was performed with the calculation of mean difference and 95% confidence intervals of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Bili), and albumin (Alb) in severe and non-severe COVID-19 patients Results: While severe COVID-19 cases displayed higher values of ALT, AST, and Bili compared to non-severe patients (mean differences of 7 48, 12 07, and 3 07, respectively), the value of Alb was significantly lower in severe cases (mean differences of - 6 15) There was also a correlation between alterations in all of the parameters;however, only correlations between ALT and Bili (R=0 98, p=0 0031), and Bili and Alb (R=-1, p=0 0012) were significant Conclusion: Abnormal values of liver-related examinations outwardly contribute to reflect the progression of the disease toward an unfavorable outcome Therefore, careful scrutiny of these parameters will provide clinicians with invaluable information regarding SARS-CoV-2 infection, at least in terms of liver injury © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases
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