PropertyValue
?:abstract
  • Patient: Male, 78-year-old Final Diagnosis: Acute generalized exanthematous pustulosis (AGEP) Symptoms: Rash Medication:— Clinical Procedure: — Specialty: Allergology • Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Acute generalized exanthematous pustulosis (AGEP) is a rare exanthem characterized by the abrupt onset of numerous small, non-follicular, sterile pustules arising on an erythematous base. AGEP is often associated with medications; however, it has also been connected to various viral infections including cytomegalovirus, parvo-virus B19, and Epstein-Barr virus. Coronavirus disease 2019 (COVID-19) has been associated with a variety of skin findings, including erythematous or patchy rash, urticaria, hives, blisters, petechiae, livedo reticularis, and even AGEP in a patient undergoing treatment with hydroxychloroquine. CASE REPORT: A 78-year-old man with a past medical history of benign prostatic hyperplasia, coronary artery disease, and atrial fibrillation presented with septic shock secondary to a urinary tract infection. On day 7 of treatment with cefepime, he became febrile and developed a pustular rash and persistent hypotension without any respiratory symptoms. Subsequently, he was diagnosed with COVID-19. Skin biopsy of the rash revealed AGEP. CONCLUSIONS: AGEP is an uncommon cutaneous eruption often triggered by medications and viruses. AGEP is thought to be mediated by pro-inflammatory cells and cytokines. This report describes an unusual presentation of AGEP following treatment with cefepime for a urinary tract infection in a 78-year-old man who was found to be positive for SARS-CoV-2 infection, but was not treated with hydroxychloroquine. Although AGEP has been described in association with some viral infections, it is more commonly a drug-associated dermatosis, commonly seen during treatment with antibiotics. As in this case, AGEP usually resolves after discontinuation of the offending antibiotic.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.12659/ajcr.926901
?:journal
  • Am_J_Case_Rep
?:license
  • cc-by-nc-nd
?:pdf_json_files
  • document_parses/pdf_json/4e71569ccd315412096f50e5b6861157598be89f.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7592336.xml.json
?:pmcid
?:pmid
?:pmid
  • 33097683.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Delayed Presentation of Acute Generalized Exanthematous Pustulosis Following Treatment with Cefepime in a Patient with COVID-19 without the Use of Hydroxychloroquine
?:type
?:year
  • 2020-10-24

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