PropertyValue
?:abstract
  • The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.bbrc.2020.10.092
?:doi
?:journal
  • Biochem_Biophys_Res_Commun
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/341423c4e3d761d7f735149522957c073f45d888.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7643664.xml.json
?:pmcid
?:pmid
?:pmid
  • 33234239.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Host-directed editing of the SARS-CoV-2 genome
?:type
?:year
  • 2020-11-05

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