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?:abstract
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Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in Regeneron’s REGN-COV2 cocktail and Eli Lilly’s LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2, as well as in lab viral escape selections. Finally, the maps reveal that mutations escaping each individual antibody are already present in circulating SARS-CoV-2 strains. Overall, these complete escape maps enable immediate interpretation of the consequences of mutations observed during viral surveillance.
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?:annotates
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?:creator
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?:doi
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10.1101/2020.11.30.405472
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?:doi
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?:journal
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?:license
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?:pdf_json_files
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document_parses/pdf_json/19920ac9a849ed9691dbc3e7a6c19303d0a3f066.json; document_parses/pdf_json/c0a72dbcb83275823c29158b368039f450c081f1.json
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?:pmcid
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?:pmid
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?:pmid
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?:publication_isRelatedTo_Disease
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?:relation_isRelatedTo_publication
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?:sha_id
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?:source
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BioRxiv; Medline; PMC; WHO
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?:title
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Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
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?:type
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?:year
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