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?:abstract
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Objective: To observe the main clinical features and outcomes of type 2 diabetes mellitus patients after infection with COVID-19 and to compare them with those without diabetes mellitus Methods: A single-center retrospective observational study was conducted in 88 in-patients who were diagnosed as COVID-19 from January 1 to February 26, 2020 They were divided into diabetic group and non-diabetic group, with 44 patients in each group Patients\' medical history, laboratory examination, in-hospital treatment plan, and disease outcome were collected and compared Results: The clinical symptoms of diabetic patients were varied, mainly fever(75 0%), cough(75 0%), fatigue(52 3%), and so on The systolic blood pressure(SBP)was higher [131 50(120 00, 140 75)vs 125 00(120 00, 131 75)mmHg, 1 mmHg=0 133 kPa, P=0 021] and the oxygenation was lower [96 00%(94 25%, 97 00%)vs 97 00%(95 00%, 98 00%), P=0 038] at admission compared with the non-diabetic group Hypertension and chronic kidney disease were more common in diabetic group Fasting blood glucose [7 64(6 12, 15 43)vs 5 62(5 25, 6 50)mmol/L, P<0 01], interleukin-6(IL-6)[19 85(6 50, 43 38)vs 10 80(3 03, 20 90)pg/ml, P=0 046] in diabetic group were significantly higher than those in non-diabetic group Secondary infection(27 3% vs 9 1%, P=0 027), ARDS(22 7% vs 4 5%, P=0 013)and shock(4 5% vs 0%, P<0 01)were more likely to occur in the diabetic group More patients were treated with mechanical ventilation in the diabetic group(20 5% vs 4 5%, P=0 024) The diabetes group was more likely to progress to critical type(20 5% vs 4 5%, P=0 024), and the time to progress to critical state was shorter [3(1 75, 5 25)vs 6(3 00, 12 00)d, P=0 019) The duration of severe symptoms was longer in the diabetic group [26 5(15 00, 31 50)vs 9(8 00, 13 00)d, P=0 026] Conclusion: The clinical symptoms of type 2 diabetes patients with COVID-19 are diverse They are often combined with diseases such as hypertension and chronic kidney disease The inflammatory reaction is more obvious and has more COVID-19 related complications and is more likely to progress into a persistent severe condition in a short time Copyright © 2020 by the Chinese Medical Association
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