| Property | Value |
|---|
|
?:abstract
|
-
OBJECTIVE: The novel coronavirus pandemic is ravaging throughout the world It has infected more than 1 2 million people and killed more than 64,000 Frantic research is underway to find prevention and cure Of late, Bacillus Calmette-Guerin (BCG) has been speculated as a possible protection from COVID-19 We sought to investigate the evidence behind the claim MATERIAL AND METHODS: Data were collected regarding the total number of COVID-19 cases per million and total number of COVID-19 deaths per million in various countries The BCG vaccination policies of these countries were also obtained RESULTS: It was seen that the countries with no universal BCG policy had a mean 1272 9 (median 795) cases per million and 80 7 deaths (median 18) per million population On the contrary, the countries with a universal BCG vaccination policy had a mean 131 2 (median 40) cases per million and 4 deaths (median 1) per population The difference is highly significant (P < 0 001) CONCLUSION: The data strongly support the hypothesis that BCG may offer protection from COVID-19 Heterologous protection offered by BCG through production of trained immunity, epigenetic reprogramming of monocytes, non-specific activation of NK cells, and increase of pro-inflammatory cytokines (particularly, tumor necrosis factor [TNF]-alpha and interleukin 1 beta) production may be the mechanism behind its cross- protection against the novel coronavirus
|
|
is
?:annotates
of
|
|
|
?:creator
|
|
|
?:journal
|
-
Indian_Journal_of_Medical_Sciences
|
|
?:license
|
|
|
?:publication_isRelatedTo_Disease
|
|
|
?:source
|
|
|
?:title
|
-
Does the Bacillus Calmette-Guerin vaccine provide protection from COVID-19?
|
|
?:type
|
|
|
?:who_covidence_id
|
|
|
?:year
|
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}