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SESSION TITLE: Medical Student/Resident Chest Infections Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: Sever coronavirus disease 2019 (COVID-19) represents viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to acute respiratory distress syndrome (ARDS) COVID-19 is a novel disease initially recognized in Wuhan, Hubei Province, China in December 2019 further declared as a global pandemic in January 2020 Along with other serious coronavirus infections, severe acute respiratory syndrome (SARS) and middle east respiratory syndrome, that also cause ARDS, COVID-19 represents an ongoing global threat as this viral family has potential to mutate and infect nonimmune patients Here we present a case of severe COVID-19 pneumonia leading to rapid ARDS requiring long hospital stay CASE PRESENTATION: 47 years old male newly diagnosed with type 2 diabetes mellitus presented to the hospital in late March with five-day history of fever, chills, body aches, and dyspnea;only known exposure was working at a gas station On admission he was febrile, tachycardic, and hypoxic requiring 4 liters via nasal canula, labs showed lymphopenia, elevated D-Dimer, LDH, CRP, ESR, and ferritin Chest x-ray with bilateral multifocal airspace opacities (Figure 1) Admitted to the medical intensive care unit (MICU) for respiratory management, seven hours after admission he acutely decompensated requiring intubation, repeat chest x-ray showed worsening of bilateral opacities consistent with ARDS (figure 2) COVID-19 testing was positive the following day Prone ventilation was initiated for 16 hours per day for a total of five days, with high PEEP, high FiO2, and tidal volumes 6ml/kg Hospitalization complicated by acute kidney injury requiring continuous renal replacement therapy/intermittent hemodialysis and atrial fibrillation requiring amiodarone drip He had prolonged mechanical ventilation and tracheotomy was delayed to high PEEP and hemodynamic lability but he had tracheotomy placement Within one week of tracheostomy, he was weaned and placed on trach collar, discharged to nursing home to work with physical therapy and work towards getting back home to his family DISCUSSION: COVID-19 pneumonia due to SARS-CoV-2 in general is an acute resolved disease with a mortality rate of 2% However, severe disease might result in death due to massive alveolar hemorrhage such as in ARDS, progressive respiratory failure, and multiorgan failure COVID-19 illness can be diagnosed by a consistent clinical history and positive SARS-CoV-2 testing COVID-19 ARDS is diagnosed when COVID-19 positive patient meets the Berlin 2012 for ARDS COVID-19 ARDS has worse outcomes compared to ARDS due to other causes, mortality can range from 65 7%-94% who received mechanical ventilation There is ongoing research for treatment of COVID-19 ARDS CONCLUSIONS: COVID-19 ARDS has worse outcomes when compared to ARDS due to other causes, there is on going research for treatment of COVID-19 related ARDS Reference #1: Singhal T (2020) A Review of Coronavirus Disease-2019 (COVID-19) Indian journal of pediatrics, 87(4), 281–286 Reference #2: Xu, Z , Shi, L , Wang, Y , Zhang, J , Huang, L , Zhang, C , Liu, S , Zhao, P , Liu, H , Zhu, L , Tai, Y , Bai, C , Gao, T , Song, J , Xia, P , Dong, J , Zhao, J , & Wang, F S (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome The Lancet Respiratory medicine, 8(4), 420–422 Reference #3: Gibson, P , Qin, L , Puah, S (2020) COVID-19 ARDS: clinical features and differences to \'usual” pre-COVID ARDS The Medical Journal of Australia DISCLOSURES: No relevant relationships by Hazim Bukamur, source=Web Response No relevant relationships by Kendall Creed, source=Web Response No relevant relationships by Jasmine Sekhon, source=Web Response No relevant relationships by Divya Vangipuram, source=Web Response
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