PropertyValue
?:abstract
  • In order to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the world, we formulate S1 subunit of the virus with two types of adjuvants, amphiphilic adjuvant monophosphoryl lipid A (MPLA) for Toll-like receptor 4 (TLR4) and CpG ODN for TLR9, into cationic multifunctional liposomes to produce a potent, safer, and translatable nanovaccine The results show that the nanovaccine can efficiently elicit humoral immune response in mice The sera from the vaccinated mice significantly inhibit SARS-CoV-2 to infect Vero cells Moreover, relatively to the free S1 with traditional Alum adjuvant, the nanovaccine can elicit strong T cell immunity by activating both CD4+ and CD8+ cells, which may play critical roles in eliminating viral load in patients Most importantly, the nanovaccine can elicit strong IgA antibody, providing potential mucosal protection to host Altogether, this study offers a translatable design for a potent subunit SARS-CoV-2 nanovaccine
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • A Translatable Subunit Nanovaccine for COVID-19
?:type
?:who_covidence_id
  • #207
?:year
  • 2020

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