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OBJECTIVE To assess clinical presentations, pregnancy complications, and maternal and neonatal outcomes among women with multiple gestation pregnancy (MGP) and confirmed SARS-CoV-2 (Covid-19) infection and to compare the data with a pre-pandemic period. METHODS A retrospective study at a dedicated Covid-19 Hospital in Mumbai, India. Data were obtained from the PregCovid Registry of pregnant and postpartum women with PCR-confirmed SARS-CoV-2 infection from April to September, 2020. Data were also compared with a cohort of women with MGP attending the hospital pre-pandemic (n=63). RESULTS Data from 879 women (singleton pregnancy, n=859; MGP, n=20) with Covid-19 were assessed. The twinning rate was 34.2 per 1000 births. As compared with singleton pregnancies, a higher proportion of women with MGP and Covid-19 delivered preterm (P=0.001). Spontaneous abortions were also higher in the MGP group than in the singleton group (P=0.055). The incidence of pre-eclampsia/eclampsia was higher in the Covid-19 MGP group than in both the Covid-19 singleton (41.6% vs 7.9%) and pre-pandemic MGP (50.0% vs 12.7%) groups. CONCLUSION There was a higher risk of pre-eclampsia among women with MGP and Covid-19. Women with MGP and Covid-19 infection should receive special attention with a multidisciplinary approach to both maternal and neonatal care during the pandemic.
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International_journal_of_gynaecology_and_obstetrics:_the_official_organ_of_the_International_Federation_of_Gynaecology_and_Obstetrics
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Impact of SARS-CoV-2 on multiple gestation pregnancy.
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