PropertyValue
?:abstract
  • Background: Little is known about changes in lymphocyte subsets after SARS-CoV-2 infection. Methods: Clinical data of 580 COVID-19 patients hospitalized in Zhongnan Hospital of Wuhan University from 20 December 2019, to 8 March 2020, were retrospectively analyzed. The relation of lymphocyte subsets and severity or prognosis of disease were analyzed. Results: At 2–3 weeks after the onset of symptoms, lymphocyte subsets decreased to the lowest levels. The levels of lymphocyte subsets in asymptomatic patients were close to healthy persons, except for CD8(+) T lymphocyte cells. The levels of lymphocyte subsets in patients with severe illness were lower than that in patients with mild-to-moderate illness (P < 0.01). Similarly, among patients with severe illness, lower levels of lymphocyte subsets were found in dead patients compared to survivors (P < 0.001). Moreover, by comparing the results of the same patients at different stages of the disease, we found levels of lymphocyte subsets were lower in the acute phase compared to that in convalescent-phase (P < 0.001). However, the levels of lymphocyte subsets in patients who had SARS-CoV-2 viral load >5000 copies/ml and 500–5000 copies/ml were at similar levels. Conclusions: Lymphocyte subsets are a good biomarker to assess the severity and prognosis of the disease at 2–3 weeks after the onset of symptoms.
?:creator
?:doi
?:doi
  • 10.1080/17476348.2021.1866991
?:journal
  • Expert_review_of_respiratory_medicine
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/3ce1d47f122f9f324392b61709032c53188e8d54.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7784778.xml.json
?:pmcid
?:pmid
?:pmid
  • 33382362.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease
?:type
?:year
  • 2020-12-31

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