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INTRODUCTION: A high-flow nasal cannula (HFNC) is an alternative device for oxygena-tion, which improves gas exchange and reduces the work of breathing Postextubation respiratory failure causes increased morbidity and mortality HFNC has been widely employed during the COVID-19 pandemic The purpose of this paper is to report a single-centre experience on the effectiveness and safety of HFNC in weaning COVID-19 patients MATERIAL AND METHODS: Nine patients showed severe acute respiratory failure and interstitial pneumonia due to SARS-CoV-2 After mechanical ventilation (5 Helmet CPAP, 4 invasive mechanical ventilation), they were de-escalated to HFNC Settings were: 34-37°C, flow from 50 to 60 L min-1 FiO2 was set to achieve appropriate SpO2 RESULTS: Nine patients (4 females;age 63 ± 13 27 years;BMI 27 2 ± 4 27) showed a baseline PaO2/FiO2 of 109 ± 45 mm Hg After a long course of ventilation all patients improved (PaO2/FiO2 336 ± 72 mm Hg) Immediately after initiation of HFNC (2 hours), PaO2/FiO2 was 254 ± 69 3 mm Hg Mean ROX index at two hours was 11 17 (range: 7 38-14 4) It was consistent with low risk of HFNC failure No difference was observed on lactate After 48 hours of HFNC oxygen therapy (day 3), mean PaO2/FiO2 increased to 396 ± 83 5 mm Hg All patients recovered from respiratory failure after 7 ± 4 1 days CONCLUSIONS: HFNC might be helpful in weaning COVID-19 respiratory failure Effectiveness and comfort should be assessed between 2 and 48 hours Clinical outcomes, oxygenation, and ROX index should be considered, to rule out the need for intubation Further evidence is required for firm conclusions We assessed psychotherapists\' and patients\' ratings of their subjective perception of meaning related to different areas of life before the COVID-19 pandemic as compared to the time during the COVID-19 pandemic In a quantitative cross-sectional study, Austrian psychotherapists (N = 222) were recruited by e-mail, who in turn recruited their patients (N = 139) Therapists and patients were asked to rate the meaning of different areas of life before as well as during the COVID-19 crisis The psychotherapists showed an overall higher rating of the importance of areas of life compared to their patients (p < 0 001) The rating of the importance of the domains of living was differently affected by the COVID-19 situation (p < 0 001) While the meaning of physical and mental health during COVID-19 was rated higher than before, the opposite was observed for work (p < 0 001) No differences were found for relationships and friends, as well as for hobbies As no interactions between perspective (therapists vs patients), area of life, and time point (before vs during COVID-19) were observed, it can be concluded that the COVID-19 situation changed the subjective attribution of meaning concerning different aspects of life similarly in therapists as well as patients While mental and physical health gained subjective importance, the opposite was observed for work
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